That big of a notable difference normally will be ‘a big deal,’ Brozak said. In its declaration, the FDA wrote that, ‘Based on available data, patients shouldn’t stop taking Vytorin or additional cholesterol-lowering drugs and really should speak to their doctor or additional health care professional if indeed they have any questions.’ The drugmakers’ jv issued a brief response repeating that statement. ‘We are delighted that the company has completed its review of the ENHANCE study,’ the firms said.. After Further Review, Vytorin Gets FDA OK The Food and Medication Administration said Thursday patients should not stop taking Vytorin or other cholesterol-lowering drugs, predicated on its just-completed review of a controversial study that hammered Vytorin sales.Advanced paternal age also increased the risk of children failing grades and having low educational attainment of less than 10 years, by 59 percent and 70 percent, respectively. Interestingly, the researchers remember that the association of advanced paternal age with suicide attempt, chemical use and academic problems strengthened after controlling for familial confounding, suggesting that shared factors correlated with advanced paternal age group have a protective impact. They replicated their findings using several family-based, quasi-experimental designs to strengthen both the external and inner validity of the findings.