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The rationale for and style of the trial, and also the statistical analysis plan, have already been published previously.12,13 The protocol was approved by the ethics committees in each participating nation and institution. An independent data and basic safety monitoring committee reviewed the info and performed one prespecified, blinded interim analysis. The steering group vouches for the accuracy and completeness of the info and analysis and for the adherence of the report to the trial protocol. Individuals We consecutively screened patients 18 years of age or older who were unconscious on entrance to a healthcare facility after out-of-hospital cardiac arrest of presumed cardiac cause, irrespective of the initial rhythm.