We want to see it when it’s being born to comprehend it better. Which will be achieved our combined experience by using this model probably. This will enable the researchers to understand what is happening also to predict an result. They will build a model to generate predictions and a biological model to test these predictions. The collaboration between the two centres will be far reaching: Material which will be ready in Boston will end up being analysed at Coleraine.The primary efficacy analysis in the protocol was amended in an analysis plan prepared in April 2008, since measurement of the % change didn’t account for chance imbalance between groups at randomization, and the mean % change had not been necessarily normally distributed . An analysis of covariance of the log10 total kidney volume at the end of the trial, with adjustment for the log10 total kidney quantity at randomization as a covariate, was used to appropriately adjust for any possibility imbalance between groupings at randomization also to provide a more specific estimate of the effect of treatment.